[Emergent viral threats in blood transfusion].

  • Pozzetto B
  • Garraud O
  • 35

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

During the last 20 years, the safety of blood products increased dramatically with regard to the infectious risk and notably to that represented by retroviruses (HIV and HTLV) and hepatitis B and C viruses. The aim of this review is to identify the residual and emergent viral threats that could be responsible for the occurring of new contaminations in the receivers of blood products. Beside many other viruses (HHV-8, erythrovirus B19, hepatitis A and E viruses...), a special attention has been paid to emerging arbovirus diseases (West Nile virus infection, dengue, chikungunya) that threaten to occur in the French metropolitan area following the implantation in Europe of the mosquito Aedes albopictus, the main vector of dengue and chikungunya in temperate regions. Another blood-linked risk, notably in United Kingdom and France, is the prion agent responsible for the variant form of the Creutzfeldt-Jakob disease. The review is concluded by a brief overview of the measures aimed to control these emergences, including the exclusion of at-risk donors, the diagnostic tests able to detect a specific agent, the leukocyte reduction of labile blood products, and the physical or chemical treatments aiming the nonspecific inactivation of infectious agents potentially present in blood without impairing significantly the physiological properties of blood compounds. The ability to control prospectively the new viral risks linked to blood products is a challenge for the preservation of the confidence of both clinicians and receivers in the safety of blood transfusion.

Author-supplied keywords

  • Aedes
  • Emerging
  • adverse effects; Communicable Diseases
  • blood/epidemiology/prevention /&/ control/transmi
  • blood; Retroviridae Infections
  • diagnosis/transmission; Virus Diseases
  • epidemiology; Forecasting; France
  • epidemiology; Humans; Insect Vectors
  • virology; Animals; Arbovirus Infections
  • virology; Leukocyte Reduction Procedures; Prions

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • B Pozzetto

  • O Garraud

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free