Enantiopure isoindolinones through Viedma ripening

  • Steendam R
  • Brouwer M
  • Huijs E
 et al. 
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Abstract

Here we demonstrate that deracemization of isoindolinones using Viedma ripening is possible starting from a racemic mixture of conglomerate crystals. Crystals of the enantiopure isoindolinones lose their chiral identity upon dissolution even without the need for a catalyst. This enabled complete deracemization of the reported isoindolinones without a catalyst.

Author-supplied keywords

  • asymmetric amplification
  • chiral resolution
  • chirality
  • grinding
  • heterocycles

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Authors

  • René R.E. Steendam

  • Maxime C.T. Brouwer

  • Evelien M.E. Huijs

  • Michaël W. Kulka

  • Hugo Meekes

  • Willem J.P. Van Enckevort

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