Enantiospecific Synthesis of Carbocyclic Aminoimidazole Carboxamide Ribonucleotide (C-Aicar), Succinoaminoimidazole Carboxamide Ribonucleotide (C-Saicar), and a New Intermediate for Saicar Analogs

Abstract

. The (-)-enantiomer of the carbocyclic analogs of aminoimidazole carboxamide ribonucleotide (C-AICAR1, 7), and succinoaminoimidazole carboxamide ribonucleotide (C-SAICAR, 14) have been prepared. En route, a new intermediate (19) for the preparation of SAICAR analogs was developed. © 1995, Taylor & Francis Group, LLC. All rights reserved.