Endocannabinoids and reactive nitrogen and oxygen species in neuropathologies.

  • Howlett A
  • Mukhopadhyay S
  • Norford D
  • 2

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Abstract

Neuropathologies that affect our population include ischemic stroke and neurodegenerative diseases of immune origin, including multiple sclerosis. The endocannabinoid system in the brain, including agonists anandamide (arachidonyl ethanolamide) and 2-arachidonoylglycerol, and the CB1 and CB2 cannabinoid receptors, has been implicated in the pathophysiology of these disease states, and can be a target for therapeutic interventions. This review concentrates on cellular signal transduction pathways believed to be involved in the cellular damage.

Author-supplied keywords

  • Animals
  • Brain
  • Brain Diseases
  • Brain Diseases: metabolism
  • Brain Diseases: pathology
  • Brain: metabolism
  • Brain: pathology
  • Endocannabinoids
  • Endocannabinoids: metabolism
  • Humans
  • Reactive Nitrogen Species
  • Reactive Nitrogen Species: metabolism
  • Reactive Oxygen Species
  • Reactive Oxygen Species: metabolism
  • Receptors, Cannabinoid
  • Receptors, Cannabinoid: metabolism
  • Signal Transduction
  • Signal Transduction: physiology

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Authors

  • Allyn C Howlett

  • Somnath Mukhopadhyay

  • Derek C Norford

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