Endocrine responses to nocturnal eating--possible implications for night work.

  • Holmbäck U
  • Forslund A
  • Lowden A
 et al. 
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Abstract

BACKGROUND: Night work is becoming more common and shift workers display several metabolic disturbances. Aim To study the endocrine responses in relation to time of day during a 24-h period and how dietary macronutrient composition affects these responses.

DESIGN: Seven males (26-43 y and 19.9-26.6 kg. m(-2)) were studied in a crossover design. Isocaloric diets described as high-carbohydrates (HC; 65 energy percent (E%) carbohydrates and 20E% fat) or high-fat (HF; 40E% carbohydrates and 45E% fat) were given. After a 6-day diet adjustment period, the subjects were kept awake for 24 h in a metabolic unit and were served an isocaloric meal (continuation of respective diet) every 4-h. Blood samples were taken throughout the 24-h period.

RESULTS: Insulin and leptin responses to meal intake differed with respect to time of day (p < 0.05). Time of day affected glucagon, thyroid stimulating hormone (TSH), free thyroxin (fT4), total triiodothyronine (tT3), cortisol, chromogranin A (CgA) and pancreatic polypeptide (PP) concentrations (p < 0.05). Meal intake decreased cortisol concentration after meals at 0800, 1200 and 0400 but not at 1600, 2000 and 0000 h. The PP's postprandial increase was greater during 0800-1600 h compared to 2000-0800 h. With the HC meals, lower glucagon and CgA concentrations (p < 0.05), and a tendency for lower tT3 concentrations (p = 0.053) were observed compared to the HF meals.

CONCLUSION: Insulin, PP, TSH, fT4, cortisol and leptin responses to meal intake differed with respect to time of day. The decreased evening/nocturnal responses of cortisol and PP to meal intake indicate that nocturnal eating and night work might have health implications.

Author-supplied keywords

  • Adult
  • Analysis of Variance
  • Circadian Rhythm
  • Circadian Rhythm: physiology
  • Cross-Over Studies
  • Dietary Carbohydrates
  • Dietary Carbohydrates: metabolism
  • Dietary Fats
  • Dietary Fats: metabolism
  • Feeding Behavior
  • Feeding Behavior: physiology
  • Hormones
  • Hormones: blood
  • Humans
  • Male
  • Neurosecretory Systems
  • Neurosecretory Systems: physiology
  • Time Factors
  • Work Schedule Tolerance
  • Work Schedule Tolerance: physiology

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Authors

  • Ulf Holmbäck

  • Anders Forslund

  • Arne Lowden

  • Jeanette Forslund

  • Torbjörn Akerstedt

  • Maria Lennernäs

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