Endogenous nitric oxide production in the airways of preterm and term infants

  • Colnaghi M
  • Condo V
  • Pugni L
 et al. 
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Abstract

Few studies have measured endogenous nitric oxide exhaled from the respiratory system of newborn infants. We measured exhaled nitric oxide (eNO) in the first 48 h of life in 24 (13 preterm, 11 term) spontaneously breathing (online method) newborns using a chemoluminescence analyzer. There was a significant difference in the eNO concentration between term and preterm healthy infants in the first 2 days of life (repeated measures analysis of variance, p < 0.05). In term infants there is a peak eNO production in the first hours of life, suggesting a potential role in postnatal adaptation, while in preterm infants eNO production is almost absent at birth, and then gradually increases. Copyright (copyright) 2003 S. Karger AG, Basel.

Author-supplied keywords

  • adaptation
  • airway
  • article
  • breathing
  • clinical article
  • controlled study
  • endogenous compound
  • exhalation
  • female
  • human
  • infant
  • male
  • nitric oxide
  • prematurity
  • priority journal

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Authors

  • M Colnaghi

  • V Condo

  • L Pugni

  • M Fumagalli

  • F Mosca

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