Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy

  • Enge M
  • Bjarneg??rd M
  • Gerhardt H
 et al. 
  • 107

    Readers

    Mendeley users who have this article in their library.
  • 227

    Citations

    Citations of this article.

Abstract

Loss of pericytes from the capillary wall is a hallmark of diabetic retinopathy, however, the pathogenic significance of this phenomenon is unclear. In previous mouse gene knockout models leading to pericyte deficiency, prenatal lethality has so far precluded analysis of postnatal consequences in the retina. We now report that endothelium-restricted ablation of platelet-derived growth factor-B generates viable mice with extensive inter- and intra-individual variation in the density of pericytes throughout the CNS. We found a strong inverse correlation between pericyte density and the formation of a range of retinal microvascular abnormalities strongly reminiscent of those seen in diabetic humans. Proliferative retinopathy invariably developed when pericyte density was

Author-supplied keywords

  • CrexP system
  • Diabetes
  • Pericytes
  • Platelet-derived growth factor
  • Retinopathy

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text

Authors

  • Maria Enge

  • Mattias Bjarneg??rd

  • Holger Gerhardt

  • Erika Gustafsson

  • Mattias Kal??n

  • Noomi Asker

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free