Endotoxemia and the host systemic response during experimental gingivitis

  • Wahaidi V
  • Kowolik M
  • Eckert G
 et al. 
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AIM: To assess endotoxemia episodes and subsequent changes in serum inflammatory biomarkers using the experimental gingivitis model. MATERIALS AND METHODS: Data from 50 healthy black and white adult males and females were compared for serum concentrations of endotoxin, and serum biomarkers [neutrophil oxidative activity, interleukin (IL)-1beta, IL-6, IL-8, C-reactive protein (CRP), and fibrinogen] at baseline, at 3 weeks of experimental gingivitis, and after 2 weeks of recovery. Means were compared using repeated measures analysis of variance. RESULTS: Endotoxemia was reported in 56% of the serum samples at 3 weeks of induced gingivitis. At 2 weeks of recovery, endotoxin levels decreased to levels similar to those reported at baseline. Neutrophil oxidative activity increased significantly following 3 weeks of gingivitis versus baseline (p

Author-supplied keywords

  • acute-phase proteins
  • cytokines
  • dental plaque
  • endotoxin
  • experimental gingivitis
  • inflammatory response
  • neutrophils

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  • Vivian Y. Wahaidi

  • Michael J. Kowolik

  • George J. Eckert

  • Dominique M. Galli

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