Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases

  • Tang Y
  • Lee T
  • Khosla C
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Abstract

Analogues of microbial secondary metabolites, which include many antibiotics and antitumor drugs, can be engineered from unusual primer units of the polyketide backbone to create new medicinal compounds with promising novel pharmacological properties.

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Authors

  • Yi Tang

  • Taek Soon Lee

  • Chaitan Khosla

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