Engineering Anti-myeloma Responses Using Affinity-Enhanced TCR-Engineered T Cells

  • San Miguel J
  • Paiva B
  • Lasarte J
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Abstract

NY-ESO-1 TCR-engineered T cells have shown activity in solid tumors. Recent work supports their use in multiple myeloma by showing that ex vivo antigen-specific expanded T cells traffic to and persist in bone marrow, are well tolerated, and produce promising response rates when infused after stem cell transplantation.

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Authors

  • Jesus F. San Miguel

  • Bruno Paiva

  • Juan Jose Lasarte

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