Enhanced drug loading in polymerized micellar cargo

  • Ogier J
  • Arnauld T
  • Carrot G
 et al. 
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A new drug carrier system based on self-assembly and polymerization of polydiacetylenic amphiphiles is described. Although classical amphiphiles can help in solubilizing hydrophobic molecules upon self-arrangement into a variety of nanometric structures, a greater effect on drug loading was observed for our polymerized micelles as compared to the non-polymerized analogues. This permitted higher aqueous solubilization of lipophilic drugs with low micelle concentration. 14C labeling of a model drug on one side and of the amphiphile on the other side permitted assessment, after intravenous injection, of biodistribution and excretion profiles of the drug cargo.

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  • Julien Ogier

  • Thomas Arnauld

  • Géraldine Carrot

  • Antoine Lhumeau

  • Jean-Marie Delbos

  • Claire Boursier

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