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Abstract

© 2017 The Royal Society of Chemistry. Synthesis, characterization and the antiproliferative activity of a new bimetallic complex [RuCp(PPh 3 ) 2 -μ-dmoPTA-1κP:2k 2 N,N′-CoCl 2 ]OTf·0.25H 2 O are described. The stability of the complex was studied under air and N 2 atmospheres and in CDCl 3 , DMSO, water and the cell culture medium, at room temperature and 40 °C. The complex showed an enhanced antiproliferative activity (up to six-fold) when compared with its parent complex [RuCp(PPh 3 ) 2 (HdmoPTA)] 2+ against human lung, cervix, breast, and colon solid tumor cell lines.

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Authors

  • Z. Mendoza

  • P. Lorenzo-Luis

  • F. Scalambra

  • J.M. Padrón

  • A. Romerosa

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