Dalton Transactions, vol. 46, issue 25 (2017)
© 2017 The Royal Society of Chemistry. Synthesis, characterization and the antiproliferative activity of a new bimetallic complex [RuCp(PPh 3 ) 2 -μ-dmoPTA-1κP:2k 2 N,N′-CoCl 2 ]OTf·0.25H 2 O are described. The stability of the complex was studied under air and N 2 atmospheres and in CDCl 3 , DMSO, water and the cell culture medium, at room temperature and 40 °C. The complex showed an enhanced antiproliferative activity (up to six-fold) when compared with its parent complex [RuCp(PPh 3 ) 2 (HdmoPTA)] 2+ against human lung, cervix, breast, and colon solid tumor cell lines.
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