Enrichment of OBO ontologies

  • Bada M
  • Hunter L
  • 37


    Mendeley users who have this article in their library.
  • 26


    Citations of this article.


This paper describes a frame-based integration of the three GO subontologies, the Chemical Entities of Biological Interest ontology, and the Cell Type Ontology in which relationships are modeled in a way that better captures the semantics between biological concepts represented by the terms, rather than between the terms themselves, than previous frame-based efforts. We also describe a methodology for creating suggested enriching assertions by identifying patterns in GO terms, mapping these patterns to new, specific relationships, and matching term substrings to concepts. Using this methodology, a predicted assertion was made for 62% of GO terms that matched one of 31 patterns, and 97% of these predicted assertions were assessed to be valid, resulting in an initial set of over 4000 assertions. Furthermore, this methodology programmatically integrates assertions into an ontology such that each assertion is fully consistent with respect to higher (i.e., more general) relevant class and slot levels. © 2006 Elsevier Inc. All rights reserved.

Author-supplied keywords

  • Gene ontology
  • Ontology consistency
  • Ontology enrichment
  • Ontology integration

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Michael Bada

  • Lawrence Hunter

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free