Enteric and disseminated Campylobacter species infection during HIV disease: A persisting but significantly modified association in the HAART era [21]

  • Manfredi R
  • Calza L
  • Chiodo F
  • 7


    Mendeley users who have this article in their library.
  • 7


    Citations of this article.


To evaluate the role of Campylobacter disease after the introduction of highly active antiretroviral therapy (HAART; introduced in late 1996), patients with at least one microbial isolation associated with consistent gastrointestinal or systemic symptoms were retrieved among patients referring every year to a tertiary centre in Bologna, Italy since 1991. Sixteen human immunodeficiency virus (HIV)-infected patients with campylobacteriosis (11 males and 5 females; aged 35.6±5.2 years; 11 diagnosed during 1991-96 and 5 during 1997-2001) were identified. The introduction of HAART caused a significant drop in the absolute frequency of campylobacteriosis (odds ratio=1.79; P0.0001). A case of haematogenous dissemination has not occurred since 1997, compared with 7 episodes diagnosed until 1996 (P0.03). Systemic involvement was observed only before the introduction of HAART (P0.03). 10 patients (9 in the pre-HAART period) received chronic co-trimoxazole prophylaxis. In vitro susceptibility assays showed elevated resistance to first generation cephalosporins (93.7%) and an increasing sensitivity rate to co-trimoxazole (43.7%), tetracyclines (50%), macrolides and chloramphenicol (62.5%), gentamicin (75%), 2nd or 3rd generation cephalosporins (81.2%) and fluoroquinolones (100%), in absence of significant temporal variations. An 8- to 18-day antimicrobial course performed with associated aminoglycosides and cephalosporins (n=8), quinolones (n=4), or macrolides (n=2) or cephalosporins (n=2) alone led to clinical and microbiological cure. Relapses caused by pathogens bearing the same antibiotic susceptibility pattern occurred in 6 patients after 3-8 weeks, all in the pre-HAART period (P0.05); one case proved lethal.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • Roberto Manfredi

  • Leonardo Calza

  • Francesco Chiodo

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free