Enterovirus 68 among children with severe acute respiratory infection, the Philippines.

  • T. I
  • N. F
  • A. S
 et al. 
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Abstract

Enterovirus 68 (EV68) is a rare enterovirus associated with respiratory illness that, unlike other enteroviruses, has been identified only from respiratory specimens. We identified EV68 from respiratory specimens of children hospitalized with a diagnosis of severe pneumonia in Leyte, Republic of the Philippines. Twenty-one samples showed high similarity with EV68 by sequencing of 5' nontranslated region; 17 of these samples were confirmed as EV68 by sequencing of viral protein 1 capsid coding region. Most previously reported EV68 cases had been identified as sporadic cases. All 21 patients we identified had severe illness, and 2 died, possibly the first reported fatal cases associated with EV68 infection. Our study suggests that EV68 may be a possible causative agent of severe respiratory illnesses.

Author-supplied keywords

  • *Enterovirus
  • *Enterovirus 68
  • *Enterovirus D
  • *Enterovirus Infections/ep [Epidemiology]
  • *Enterovirus infection/di [Diagnosis]
  • *Enterovirus infection/et [Etiology]
  • *Pneumonia
  • *nucleotide sequence
  • *respiratory tract infection/di [Diagnosis]
  • *respiratory tract infection/et [Etiology]
  • 5' untranslated region
  • Acute Disease
  • Adolescent
  • Child Mortality
  • DNA
  • Enterovirus D
  • Enterovirus Infections/mo [Mortality]
  • Enterovirus Infections/pp [Physiopathology]
  • Enterovirus Infections/vi [Virology]
  • Hospitalization/sn [Statistics & Numerical Data]
  • Human/cl [Classification]
  • Human/ge [Genetics]
  • Human/ip [Isolation & Purification
  • Humans
  • Molecular Sequence Data
  • Newborn
  • Philippines
  • Philippines/ep [Epidemiology]
  • Phylogeny
  • Preschool
  • RNA extraction
  • Severity of Illness Index
  • Viral/ep [Epidemiology]
  • Viral/mo [Mortality]
  • Viral/pp [Physiopathology]
  • Viral/vi [Virology]
  • amino acid sequence
  • article
  • child
  • disease association
  • disease severity
  • female
  • hospitalization
  • human
  • infant
  • major clinical study
  • male
  • mortality
  • nose smear
  • pathogenesis
  • pneumonia
  • polymerase chain reaction
  • preschool child
  • protein VP1
  • retrospective study
  • school child
  • sequence analysis
  • sequence homology
  • throat culture
  • virus identification

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Authors

  • Imamura T.

  • Fuji N.

  • Suzuki A.

  • Tamaki R.

  • Saito M.

  • Aniceto R.

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