Environmental and behavioral influences on gene activity

  • Gottlieb G
  • 91


    Mendeley users who have this article in their library.
  • 48


    Citations of this article.


The central dogma of molecular biology holds that "information" flows from the genes to the structure of the proteins that genes bring about through the formula DNA -> RNA -> protein. In this view, a set of master genes activates the DNA necessary to produce the appropriate proteins that the organism needs during development. In contrast to this view, probabilistic epigenesis holds that necessarily there are signals from the internal and external environment that activate DNA to produce the appropriate proteins. To support this view, I review a substantial body of evidence showing that external environmental influences on gene activation are normally occurring events in a large variety of organisms, including humans. This demonstrates how genes and environments work together to produce functional organisms, thus extending the model of probabilistic epigenesis.

Author-supplied keywords

  • Central dogma
  • Predetermined epigenesis
  • Probabilistic epigenesis

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • Gilbert Gottlieb

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free