Eosinophilic esophagitis

  • Couto M
  • Rodrigues S
  • Piedade S
 et al. 
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Eosinophilic esophagitis (EE) is an inflammatory disease of the esophagus characterized by significant and isolated infiltration of the esophageal mucosa by eosinophils, associated with clinical symptoms of esophageal dysfunction, affecting children and adults. It is an increasingly frequent cause of symptoms similar to gastroesophageal reflux disease but refractory to anti-acid therapeutic. It is commonly associated with food allergies or other atopic diseases. Since there are no symptoms, signs, serological biomarkers or endoscopic findings pathognomonic of EE, the diagnosis requires a high degree of suspicion; moreover, due to its chronic relapsing nature the potential to cause major esophageal structural changes, its early recognition and close cooperation between gastroenterologists and immunoallergologists is essential for the timely institution of appropriate therapy. The treatment is based on two main strategies: diet and / or pharmacotherapy, depending on the co-existence of sensitization to food allergens. It is our aim to review this issue, considering recent guidelines, as well as propose a diagnostic and therapeutic algorithm.

Author-supplied keywords

  • 48:Gastroenterology
  • Embase
  • acid
  • adult
  • algorithm
  • atopy
  • child
  • diagnosis
  • diet
  • drug therapy
  • endoscopy
  • eosinophil
  • eosinophilic esophagitis -- diagnosis
  • esophagus
  • esophagus mucosa
  • food allergen
  • food allergy
  • gastroesophageal reflux
  • human
  • inflammatory disease
  • practice guideline
  • review
  • sensitization
  • therapy

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

There are no full text links


  • Mariana Couto

  • Susana Rodrigues

  • Susana Piedade

  • Ângela Gaspar

  • Mário Morais-Almeida

  • Guilherme Macedo

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free