EpCAM: Another Surface-to-Nucleus Missile

  • Carpenter G
  • Red Brewer M
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The epithelial-specific cell adhesion molecule (EpCAM) modulates cell adhesion and proliferation. Its overexpression correlates with tumor cell proliferation, and EpCAM is a therapeutic target. In the February issue of Nature Cell Biology, Maetzel et al. demonstrate that proliferative responses to EpCAM require regulated intramembrane proteolysis and a nucleocytoplasmic intracellular domain fragment. © 2009 Elsevier Inc. All rights reserved.

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  • Graham Carpenter

  • Monica Red Brewer

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