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EpCAM: Another Surface-to-Nucleus Missile

Cancer Cell
DOI: 10.1016/j.ccr.2009.02.005
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Abstract

The epithelial-specific cell adhesion molecule (EpCAM) modulates cell adhesion and proliferation. Its overexpression correlates with tumor cell proliferation, and EpCAM is a therapeutic target. In the February issue of Nature Cell Biology, Maetzel et al. demonstrate that proliferative responses to EpCAM require regulated intramembrane proteolysis and a nucleocytoplasmic intracellular domain fragment. © 2009 Elsevier Inc. All rights reserved.

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Carpenter, G., & Red Brewer, M. (2009, March 3). EpCAM: Another Surface-to-Nucleus Missile. Cancer Cell. Cell Press. https://doi.org/10.1016/j.ccr.2009.02.005

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