Epidemiology of Human Papillomavirus-Related Head and Neck Cancer

  • Joseph A
  • D'Souza G
  • 2

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Abstract

Human papillomavirus (HPV) is now recognized to cause a subset of head and neck squamous cell carcinomas (HNSCC). Although excessive tobacco and alcohol use continue to be important risk factors for HNSCC, epidemiologic studies suggest that more than 25% of HNSCC are now caused by HPV. The incidence of HPV-related HNSCC is increasing, highlighting the need to understand the oral HPV infections causing these cancers. This article reviews the evidence for a causal association between HPV and HNSCC, examines the changing epidemiologic trends of HNSCC, and discusses what is currently known about oral HPV infection, natural history, and transmission.

Author-supplied keywords

  • Carcinoma
  • Epidemiology
  • HPV
  • Head and Neck Neoplasms
  • Head and Neck Neoplasms: epidemiology
  • Head and Neck Neoplasms: virology
  • Head and neck cancer
  • Human papillomavirus
  • Humans
  • Incidence
  • Oropharyngeal cancer
  • Papillomaviridae
  • Papillomavirus Infections
  • Papillomavirus Infections: epidemiology
  • Squamous Cell
  • Squamous Cell: epidemiology
  • Squamous Cell: virology
  • Squamous cell carcinoma

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Authors

  • Andrew W. Joseph

  • Gypsyamber D'Souza

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