Erwin Schroedinger, Francis Crick and epigenetic stability

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Abstract

Schroedinger's book 'What is Life?' is widely credited for having played a crucial role in development of molecular and cellular biology. My essay revisits the issues raised by this book from the modern perspective of epigenetics and systems biology. I contrast two classes of potential mechanisms of epigenetic stability: 'epigenetic templating' and 'systems biology' approaches, and consider them from the point of view expressed by Schroedinger. I also discuss how quantum entanglement, a nonclassical feature of quantum mechanics, can help to address the 'problem of small numbers' that led Schroedinger to promote the idea of a molecular code-script for explaining the stability of biological order. © 2008 Ogryzko; licensee BioMed Central Ltd.

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Ogryzko, V. V. (2008). Erwin Schroedinger, Francis Crick and epigenetic stability. Biology Direct, 3. https://doi.org/10.1186/1745-6150-3-15

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