Erythropoietin and acute renal failure

  • Sharples E
  • Yaqoob M
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Abstract

The hemopoietic growth factor erythropoietin (EPO) has been recognized to be a multifunctional cytokine that plays a key role in ischemic preconditioning in the brain and heart. The EPO receptor is expressed widely in the kidney, and we review the important findings from the use of EPO in experimental models of acute renal failure that show that EPO reduces tubular cell death and hence the dysfunction induced by ischemia reperfusion injury, and we explore how these observations may be translated into the clinical arena

Author-supplied keywords

  • 0
  • Acute
  • Animals
  • Apoptosis
  • Brain
  • Brain Ischemia
  • Cell Death
  • Critical Care
  • Erythropoietin
  • Heart
  • Humans
  • Ischemia
  • Ischemic Preconditioning
  • Kidney
  • Kidney Failure
  • Kidney Tubules
  • London
  • Medicine
  • Nephrology
  • Observation
  • Proximal
  • Recombinant
  • Reperfusion Injury
  • Research
  • acute renal failure
  • blood supply
  • drug effects
  • drug therapy
  • injuries
  • pathology
  • physiopathology
  • renal failure
  • therapeutic use

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  • PMID: 16949472

Authors

  • E J Sharples

  • M M Yaqoob

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