Escherichia coli and its chromosome.

  • Reyes-Lamothe R
  • Wang X
  • Sherratt D
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The Escherichia coli chromosome is a circular DNA molecule that is
approximately 1000 times compacted in the living cell, where it occupies
approximately 15% of the cellular volume. The genome is organized
in a way that facilitates chromosome maintenance and processing.
Despite huge efforts, until recently little has been known about
how the chromosome is organized within cells, where replication takes
place, and how DNA is segregated before cell division. New techniques
for labeling genetic loci and molecular machines are allowing the
simultaneous tracking of genetic loci and such machines in living
cells over time. These studies reveal remarkable organization, yet
a highly dynamic flux of genetic loci and macromolecules. It seems
likely that the cellular positioning of chromosomal loci is the outcome
of the formation of two chromosome arms (replichores) by replication,
followed by sequential chromosome segregation, rather than from the
presence of cellular positioning markers.

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  • Rodrigo Reyes-Lamothe

  • Xindan Wang

  • David Sherratt

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