Escherichia coli and its chromosome.

  • Reyes-Lamothe R
  • Wang X
  • Sherratt D
  • 1

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

The Escherichia coli chromosome is a circular DNA molecule that is
approximately 1000 times compacted in the living cell, where it occupies
approximately 15% of the cellular volume. The genome is organized
in a way that facilitates chromosome maintenance and processing.
Despite huge efforts, until recently little has been known about
how the chromosome is organized within cells, where replication takes
place, and how DNA is segregated before cell division. New techniques
for labeling genetic loci and molecular machines are allowing the
simultaneous tracking of genetic loci and such machines in living
cells over time. These studies reveal remarkable organization, yet
a highly dynamic flux of genetic loci and macromolecules. It seems
likely that the cellular positioning of chromosomal loci is the outcome
of the formation of two chromosome arms (replichores) by replication,
followed by sequential chromosome segregation, rather than from the
presence of cellular positioning markers.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

There are no full text links

Authors

  • Rodrigo Reyes-Lamothe

  • Xindan Wang

  • David Sherratt

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free