Essentials of biorecognition: The (strept)avidin-biotin system as a model for protein-protein and protein-ligand interaction

  • Wilchek M
  • Bayer E
  • Livnah O
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Abstract

Molecular recognition or biorecognition is as the heart of all biological interactions. These interactions are characterized by a collection of noncovalent bonds, namely ionic, hydrogen-bonding and hydrophobic interactions. In addition, shape complementarity appears to play a pivotal role in the process of biorecognition. In this review, we examine the versatile avidin-biotin complex as a model system for study of the biorecognition phenomenon with respect to protein-protein, protein-peptide, protein-ligand and protein-DNA interactions. © 2005 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • Avidin
  • Catalysis
  • Protein-ligand
  • Protein-protein
  • Streptavidin

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Authors

  • Meir Wilchek

  • Edward A. Bayer

  • Oded Livnah

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