Establishing bacterial communities by 'word of mouth': LuxS and autoinducer 2 in biofilm development

  • Hardie K
  • Heurlier K
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Multicellular bacterial communities (biofilms) abound in nature, and their successful formation and survival is likely to require cell-cell communication--including quorum sensing--to co-ordinate appropriate gene expression. The only mode of quorum sensing that is shared by both Gram-positive and Gram-negative bacteria involves the production of the signalling molecule autoinducer 2 by LuxS. A survey of the current literature reveals that luxS contributes to biofilm development in some bacteria. However, inconsistencies prevent biofilm development being attributed to the production of AI2 in all cases.

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  • Kim Rachael Hardie

  • Karin Heurlier

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