Establishment of reference intervals for soluble ST2 from a United States population

  • Lu J
  • Snider J
  • Grenache D
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Abstract

Background. Soluble ST2 (sST2) is a protein in the interleukin-1 receptor family secreted by myocytes in response to mechanical strain Elevated sST2 is strongly prognostic in patients with heart failure Methods sST2 was measured using the Presage (TM) ST2 ELISA. Evaluation included imprecision, linearity, recovery, analytical sensitivity, limit of quantification, stability. and sample type comparisons Gender-specific reference intervals were established from 245 male and 245 female serum specimens Results. At sST2 concentrations of 11 6. 269, and 88.0 ng/ml, the within-day CV was 76, 24, and 3 8%. respectively and the total CV was 11.5, 14 0. and 6.3%, respectively The assay was linear over a concentration range of 2 8-161.1 ng/mL (y= 0 95+4- 2 25, R(2)=0.997, Sy x =3 03) The limit of quantification was 3.3 ng/mL. sST2 was stable for 2 clays at room temperature. 10 days at 4 C, and 30 days at 20 C Concentrations of sST2 were significantly higher in males compared to females (24 9 vs 16 9 ng/mL, p

Author-supplied keywords

  • acute dyspnea
  • cardiovascular disease
  • heart failure
  • mortality
  • myocardial-infarction
  • plasma
  • receptor family-member
  • reference intervals
  • st2

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Authors

  • J Lu

  • J V Snider

  • D G Grenache

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