Estimation of glucose level and body weight in Alloxan Induced Diabetic Rat treated with Aqueous extract of Garcinia Kola Seed

Abstract

Background: Garcinia kola (GK) is a species of flowering plant in the Clusiaceae or Guttiferae family. Hypoglyceamic effect of GK was evaluated in alloxan induced diabetic rats. Method: Eighteen male wistar albino rats of weights between 158-172g were divided into three groups named A to C. Group A was given distilled water (d/w) throughout the experiment; diabetes was induced in group B and C. Group B was given d/w but not GK while group C was treated with GK extract for 21 days. Fasting blood samples were collected at baseline, 24 hours, 7th, 14th and 21st day for blood glucose evaluation. Result: Mean fasting blood glucose (FBG) level was significantly higher (P<0.001) after 24 hours diabetes induction with alloxan in groups B and C rats compared to the baseline. Group B showed geometric increase in FBG level and decrease in body weight from 24 hours after diabetes induction to the 21st day of study duration. Group C rats had significantly lower (P<0.001) mean FBG level than Group B rats. Significant difference in body weight was observed among the 3 groups throughout the study periods but for baseline. Conclusion: Treatment of alloxan induced diabetic rats with GK extract lowers blood glucose level and restores weight loss. Key