Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome

  • Ikonomidou C
  • Bittigau P
  • Koch C
 et al. 
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Abstract

The deleterious effects of ethanol on the developing human brain are poorly understood. Here it is reported that ethanol, acting by a dual mechanism [blockade ofN-methyl-D-aspartate (NMDA) glutamate receptors and excessive activation of GABAA receptors], triggers widespread apoptotic neurodegenera- tion in the developing rat forebrain. Vulnerability coincides with the period of synaptogenesis, which in humans extends from the sixth month of gestation to several years after birth. During this period, transient ethanol exposure can delete millions of neurons from the developing brain. This can explain the reduced brain mass and neurobehavioral disturbances associated with human fetal alcohol syndrome.

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Authors

  • Chrysanthy Ikonomidou

  • Petra Bittigau

  • Christian Koch

  • Kerstin Genz

  • Vanya Stefovska

  • Friederike Hörster

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