Ethnic and sex differences in circulating endotoxin levels: A novel marker of atherosclerotic and cardiovascular risk in a British multi-ethnic population

  • Miller M
  • McTernan P
  • Harte A
 et al. 
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Abstract

Background: Circulating endotoxin levels are associated with atherosclerosis. Moreover, ethnic differences in pro-inflammatory markers may be associated with ethnic differences in atherosclerotic and cardiovascular (CVD) and coronary heart disease (CHD) risk. Objective and methods: To investigate ethnic differences in circulating plasma endotoxin levels, its soluble receptor (sCD14), and high-sensitivity CRP (hs-CRP). 192 individuals, aged 40-59 years (61 white (30 women), 68 of African origin (33 women) and 63 South Asians (33 women)), free from coronary heart disease (CHD), stroke, CVD and diabetes were randomly selected from the UK 'Wandsworth Heart and Stroke Study'. Results: Age-adjusted endotoxin levels were lower in women than in men (p = 0.002) and were highest in South Asians (13.3 EU/mL [95% CI 12.0-14.7]) and lowest in individuals of African origin (10.1 EU/mL [9.1-11.1]) than in whites (p for linear trend

Author-supplied keywords

  • Atherosclerosis
  • Cardiovascular
  • Endotoxin
  • Ethnicity

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Authors

  • Michelle A. Miller

  • Philip G. McTernan

  • Alison L. Harte

  • Nancy F.da Silva

  • Pasquale Strazzullo

  • K. George M.M. Alberti

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