To evaluate how functional disability impacts on health related quality
of life (HRQOL) of patients with extremity soft tissue sarcoma (STS) at
1 year post-surgery. Survey of extremity STS patients pre-surgery and
one-year post-treatment.100 participants who were treated for extremity
STS between 2001 and 2003 at four Canadian hospitals. Patients were over
16 years, non-metastatic at diagnosis, and had limb salvage surgery.
Musculoskeletal Tumor Society Rating Scale (MSTS), a measure of
impairment; Toronto Extremity Salvage Score (TESS), a measure of
activity limitations; Reintegration to Normal Living Index (RNL), a
measure of participation restrictions; and EQ-VAS, a measure of HRQOL.
After adjusting for demographic and clinical variables, impairment
explained 54%, activity limitations explained 48%, and participation
restrictions explained 61% of the variation in HRQOL. After adjustment,
when all three functional measures were included in the model, only
participation restrictions had a significant impact on HRQOL explaining
63% of the variation. Impairment and activity limitations affect the
daily activities a patient can perform, but it is the restriction in
participation of life roles and situations that has the greatest effect
on patient's HRQOL.
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