Evaluation of the combined antimicrobial activity of the leaf extract of phyllantus muellerianus with ciprofloxacin

  • Ofokansi K
  • Attama A
  • Uzor P
 et al. 
  • 26

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Abstract

Background: Infectious diseases caused by multi-resistant microbial strains are on the increase. Fighting these diseases with natural products may be more efficacious. The aim of this study was to investigate the in vitro antimicrobial activity of methanol leaf extract and chromatographic fractions of the extract of Phyllanthus muellerianus (Kuntze) Excell against Klebsiella spp., Enterococcus faecalis, Pseudomonas earuginosa, Proteus mirabilis, Escherichia coli, Salmonella spp. and Candida albicans. The combined effect of the extract or its fractions with ciprofloxacin was also tested. Methods: The antimicrobial properties of the methanol extract of P. muellerianus and its fractions were determined in vitro using the agar diffusion method. Agar diffusion Checkerboard method and Overlay Inoculum susceptibility disc method were used to study the interaction of the extract or fraction with ciprofloxacin. The extract was subjected to phytochemical analysis for identification of constituents using standard procedures. The minimum inhibitory concentration (MIC) data obtained from the antimicrobial studies were analyzed for significant difference at p

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Authors

  • Kenneth C Ofokansi

  • Anthony A Attama

  • Philip F Uzor

  • Mercy O Ovri

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