Evaluation of Dementia Rating Scales in Parkinson's Disease Dementia

  • Harvey P
  • Ferris S
  • Cummings J
 et al. 
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Disease-specific assessments are not currently available for patients with Parkinson's disease dementia (PDD). This study evaluated the criterion-related validity and test-retest reliability of the Alzheimer's Disease Assessment scale cognitive subscale (ADAS-cog) in terms of sensitivity for differentiation between mild and moderate severity impairment in PDD. Six other dementia rating scales and cognitive tests were also examined. A total of 113 patients with PDD or Alzheimer disease were recruited into this 4-week, multicenter study, segregated into 2 severity groups based on Mini-Mental State Examination (MMSE) score. Mean ADAS-cog scores showed a statistically significant separation between mild and moderate severity patients in both dementias (P < .001). For the ADAS-cog, test-retest Spearman correlation coefficients were significant for each dementia type and severity. This study demonstrated the criterion-related validity and test-retest reliability for ADAS-cog in patients with PDD and strong correlations with MMSE. This supports the validity of previous results obtained with these measures in studies of patients with PDD

Author-supplied keywords

  • 2
  • Alzheimer Disease
  • Alzheimer's Disease
  • Disease
  • Group
  • Impairment
  • Multicenter Studies
  • Parkinson's
  • Patients
  • Separation
  • State
  • Support
  • Total
  • correlation-coefficient
  • reliability
  • studies

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  • PMID: 19359706


  • P D Harvey

  • S H Ferris

  • J L Cummings

  • K A Wesnes

  • C Hsu

  • R M Lane

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