Evaluation of in vivo antitumor effects of ANT2 shRNA delivered using PEI and ultrasound with microbubbles

  • Park D
  • Jung B
  • Lee Y
 et al. 
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Abstract

Gene therapy using RNA interference can be directed against tumors through various strategies, but has been hindered owing to the inefficiency of non-viral delivery. To evaluate the antitumor effects of adenine nucleotide translocase-2 (ANT2) short hairpin RNA (shRNA) by intraperitoneal injection using the polyethylenimine (PEI) and an ultrasound gene delivery method, human breast carcinoma MDA-MB-231 cells were injected subcutaneously into NOG (NOD/Shi-scid/IL-2Rγ null) mice. The results showed greater tumor regression (∗P

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Authors

  • Hyunjin ParkSungkyunkwan University - Suwon Campus

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  • D. H. Park

  • B. K. Jung

  • Y. S. Lee

  • J. Y. Jang

  • M. K. Kim

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