Evidence for characteristic vascular patterns in solid tumours: Quantitative studies using corrosion casts

178Citations
Citations of this article
105Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The vascular architecture of four different tumour cell lines (CaX, CaNT, SaS, HEC-1B) transplanted subcutaneously in mice was examined by means of microvascular corrosion casting in order to determine whether there is a characteristic vascular pattern for different tumour types and whether it differs significantly from two normal tissues, muscle and gut. Three-dimensional reconstructed scanning electron microscope images were used for quantitative measurements. Vessel diameters, intervessel and interbranch distances showed large differences between tumour types, whereas the branching angles were similar, in all tumours, the variability of the vessel diameters was significantly higher than in normal tissue. The quantitative data provide strong evidence for a characteristic vascular network determined by the tumour cells themselves.

Cite

CITATION STYLE

APA

Konerding, M. A., Malkusch, W., Klapthor, B., Van Ackern, C., Fait, E., Hill, S. A., … Denekamp, J. (1999). Evidence for characteristic vascular patterns in solid tumours: Quantitative studies using corrosion casts. British Journal of Cancer, 80(5–6), 724–732. https://doi.org/10.1038/sj.bjc.6690416

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free