Evidence and consequences of the central role of the kidneys in the pathophysiology of sympathetic hyperactivity

  • Vink E
  • Blankestijn P
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Chronic elevation of the sympathetic nervous system has been identified as a major contributor to the complex pathophysiology of hypertension, states of volume overload - such as heart failure - and progressive kidney disease. It is also a strong determinant for clinical outcome. This review focuses on the central role of the kidneys in the pathogenesis of sympathetic hyperactivity. As a consequence, renal denervation may be an attractive option to treat sympathetic hyperactivity. The review will also focus on first results and the still remaining questions of this new treatment option.

Author-supplied keywords

  • Hypertension
  • Kidney disease
  • Renal denervation
  • Sympathetic activity

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  • Eva E. Vink

  • Peter J. Blankestijn

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