Exercise, cachexia, and cancer therapy: A molecular rationale

  • Ardies C
  • 40

    Readers

    Mendeley users who have this article in their library.
  • 38

    Citations

    Citations of this article.

Abstract

Evidence from recent publications indicates that repeated exercise may enhance the quality of life of cancer patients. The lack of reported negative effects and the consis-tency of the observed benefits lead one to conclude that physi-cal exercise may provide a low-risk therapy that can improve patients' capacity to perform activities of daily living and im-prove their quality of life. Repeated physical activity may at-tenuate the adverse effects of cancer therapy, prevent or reverse cachexia, and reduce risk for a second cancer through suppression of inflammatory responses or enhance-ment of insulin sensitivity, rates of protein synthesis, and anti-oxidant and phase II enzyme activities. These results most likely come about through the ability of physical exercise to attenuate a chronic inflammatory signaling process and to transiently activate the mitogen-activated protein kinase, c-Jun NH 2 -terminal kinase, c-Jun NH 2 -terminal kinase-mito-gen-activated protein kinase, and nuclear factor-κB pathways and through its ability to enhance insulin sensitivity. Ex-panded molecular-based research into these areas may pro-vide new insights into the biological mechanisms associated with cancer rehabilitation and endogenous risk.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • C. Murray Ardies

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free