Exploring the role of cancer stem cells in radioresistance

  • Baumann M
  • Krause M
  • Hill R
  • 1

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

Radiobiological research over the past decades has provided evidence that cancer stem cell content and the intrinsic radiosensitivity of cancer stem cells varies between tumours, thereby affecting their radiocurability. Translation of this knowledge into predictive tests for the clinic has so far been hampered by the lack of methods to discriminate between stem cells and non-stem cells. New technologies allow isolation of cells expressing specific surface markers that are differentially expressed in tumour cell subpopulations that are enriched for cancer stem cells. Combining these techniques with functional radiobiological assays holds the potential to elucidate the role of cancer stem cells in radioresistance in individual tumours, and to use this knowledge for the development of predictive markers for optimization of radiotherapy

Author-supplied keywords

  • *Radiation Tolerance
  • Animals
  • Humans
  • Neoplasms
  • Neoplasms/pathology/*radiotherapy
  • Neoplastic Stem Cells
  • Neoplastic Stem Cells/*cytology
  • Radiation Oncology
  • Radiation Tolerance
  • Stem Cells
  • cytology
  • methods
  • pathology
  • radiotherapy

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • M Baumann

  • M Krause

  • R Hill

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free