Expression of CD40 in the brain of Alzheimer's disease and other neurological diseases

  • Togo T
  • Akiyama H
  • Kondo H
 et al. 
  • 33


    Mendeley users who have this article in their library.
  • 97


    Citations of this article.


We have investigated immunohistochemically the expression of CD40 in post-mortem human brain tissues. In control brain, the blood vessels were stained weakly for CD40. Vascular expression of CD40 was enhanced in the lesions of Alzheimer's disease and some other neurological diseases. In such diseases, reactive microglia were also positive for CD40. The results of this study suggest that CD40 expression by microglia is up-regulated upon a variety of brain insults and is not limited to lesions with amyloid β-protein deposits. Copyright (C) 2000 Elsevier Science B.V.

Author-supplied keywords

  • Amyloid β-protein
  • Blood vessel
  • Inflammation
  • Microglia

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Takashi Togo

  • Haruhiko Akiyama

  • Hiromi Kondo

  • Kenji Ikeda

  • Masanori Kato

  • Eizo Iseki

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free