Extra centrosomes and/or chromosomes prolong mitosis in human cells

  • Yang Z
  • Lončarek J
  • Khodjakov A
 et al. 
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Abstract

Using laser microsurgery and cell fusion we have explored how additional centrosomes and/or chromosomes influence the duration of mitosis in human cells. We found that doubling the chromosome number added approximately 10 min to a 20 min division, whereas doubling the number of centrosomes added approximately 30 min more. Extra centrosomes and/or chromosomes prolong mitosis by delaying satisfaction of the spindle assembly checkpoint. Thus mitosis can be prolonged by non-genetic means and extra chromosomes and centrosomes probably contribute to the elevated mitotic index seen in many tumours.

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Authors

  • Zhenye Yang

  • Jadranka Lončarek

  • Alexey Khodjakov

  • Conly L. Rieder

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