The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis

  • Chang C
  • Werb Z
  • 1

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

Metalloproteases are important in many aspects of biology, ranging from cell proliferation, differentiation and remodeling of the extracellular matrix (ECM) to vascularization and cell migration. These events occur several times during organogenesis in both normal development and during tumor progression. Mechanisms of metalloprotease action underlying these events include the proteolytic cleavage of growth factors so that they can become available to cells not in direct physical contact, degradation of the ECM so that founder cells can move across tissues into nearby stroma, and regulated receptor cleavage to terminate migratory signaling. Most of these processes require a delicate balance between the functions of matrix metalloproteases (MMPs) or metalloprotease-disintegrins (ADAMs) and natural tissue inhibitors of metalloproteases (TIMPs). In this review, we discuss recent progress in identifying an essential role for metalloproteases in axon outgrowth, as an example of a focal invasive event. We also discuss the evolving concept of how MMPs might regulate stem cell fate during tumor development

Author-supplied keywords

  • ADAM disintegrin
  • Biology
  • Cell fate
  • Cell migration
  • Cells
  • Differentiation
  • Extracellular Matrix
  • Face
  • Growth Factor
  • Metalloproteinase
  • Migration
  • Natural
  • Physical
  • Receptor
  • Time
  • Tumor
  • axon
  • axon pathfinding
  • cell motility
  • cell proliferation
  • cell signalling
  • development
  • extracellular matrix (ECM)
  • growth
  • inhibitors
  • metalloprotease
  • metastasis
  • neurodevelopment
  • review
  • tumor invasion

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

There are no full text links

Authors

  • Chieh Chang

  • Zena Werb

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free