Factors Associated With Isolated Right Heart Failure in Women

  • Lagat D
  • DeLong A
  • Wellenius G
 et al. 
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Abstract

Background: Small observational studies have found that isolated right heart failure (IRHF) is prevalent among women of sub-Saharan Africa. Further, several risk factors for the development of IRHF have been identified. However, no similar studies have been conducted in Kenya. Objective: We hypothesized that specific environmental exposures and comorbidities were associated with IRHF in women of western Kenya. Methods: We conducted a case-control study at a referral hospital in western Kenya. Cases were defined as women at least 35 years old with IRHF. Control subjects were similarly aged volunteers without IRHF. Exclusion criteria in both groups included history of tobacco use, tuberculosis, or thromboembolic disease. Participants underwent echocardiography, spirometry, 6-min walk test, rest/exercise oximetry, respiratory health interviews, and human immunodeficiency virus (HIV) testing. Home visits were performed to evaluate kitchen ventilation, fuel use, and cook smoke exposure time, all surrogate measures of indoor air pollution (IAP). A total of 31 cases and 65 control subjects were enrolled. Surrogate measures of indoor air pollution were not associated with IRHF. However, lower forced expiratory volume at 1 s percent predicted (adjusted odds ratio [AOR]: 2.02, 95% confidence interval [CI]: 1.27 to 3.20; p¼0.004), HIV positivity (AOR: 40.4, 95% CI: 3.7 to 441; p

Author-supplied keywords

  • Cookstove
  • Indoor air pollution
  • health

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Authors

  • David K. Lagat

  • Allison K. DeLong

  • Gregory a. Wellenius

  • E. Jane Carter

  • Gerald S. Bloomfield

  • Eric J. Velazquez

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