Factors associated with long-term mortality in acute pancreatitis.

  • C. N
  • P. M
  • F. B
 et al. 
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Abstract

Background and aims. Knowledge of the long-term prognosis of acute pancreatitis (AP) is limited. The aims were to investigate: (1) prognostic factors associated with long-term mortality in patients with AP; (2) whether or not the level of serum (S-)amylase at admission had an impact on the prognosis; (3) causes of death in these patients. Methods. During 1977-1982, patients who were admitted to the five main hospitals in Copenhagen with a diagnosis of AP or chronic pancreatitis (CP) were included in a prospective cohort, the Copenhagen Pancreatitis Study (CPS); in 2008, they were followed up by linkage to the Danish Registries. The analyzed subcohort consisted of 352 patients with probable AP (n = 54) or definite AP (n = 298). Results. Multivariate Cox regression analysis showed that significant factors associated with mortality were age, alcohol, and diabetes, whereas female gender, co-living and employment were associated with better survival. The S-amylase level had no impact on mortality. The most frequent causes of death were cardiovascular diseases, digestive diseases, and malignancies. Conclusions. Age, alcohol and diabetes had a significant impact on survival whereas the S-amylase level did not. (copyright) 2011 Informa Healthcare.

Author-supplied keywords

  • Abdominal Pain
  • Abdominal Pain: etiology
  • Adult
  • Age Factors
  • Aged
  • Alcohol Drinking
  • Alcohol Drinking: adverse effects
  • Amylases
  • Amylases: blood
  • Cardiovascular Diseases
  • Cardiovascular Diseases: mortality
  • Cause of Death
  • Denmark
  • Denmark: epidemiology
  • Diabetes Complications
  • Female
  • Follow-Up Studies
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Neoplasms
  • Neoplasms: mortality
  • Pancreatitis
  • Pancreatitis: diagnosis
  • Pancreatitis: mortality
  • Prognosis
  • Proportional Hazards Models
  • Sex Factors
  • Young Adult
  • accident
  • acute pancreatitis
  • adult
  • age distribution
  • aged
  • alcohol consumption
  • alcohol liver disease
  • alkaline phosphatase
  • alkaline phosphatase blood level
  • amylase
  • amylase blood level
  • analgesic agent
  • article
  • aspartate aminotransferase
  • aspartate aminotransferase blood level
  • bilirubin
  • bilirubin blood level
  • blood clotting factor
  • body mass
  • calcium
  • calcium blood level
  • cardiovascular disease
  • cause of death
  • cerebrovascular accident
  • cohort analysis
  • controlled study
  • creatinine
  • creatinine blood level
  • dementia
  • diabetes mellitus
  • diet restriction
  • disease registry
  • employment status
  • female
  • gamma glutamyl transferase blood level
  • gamma glutamyltransferase
  • gastrointestinal disease
  • gynecologic disease
  • hemoglobin
  • hospital admission
  • hospitalization
  • human
  • infection
  • liver cirrhosis
  • major clinical study
  • male
  • mental disease
  • mortality
  • multicenter study
  • opiate
  • pancreas cancer
  • pancreas resection
  • pancreaticojejunostomy
  • priority journal
  • prognosis
  • prospective study
  • respiratory tract disease
  • sex difference
  • survival rate
  • survival time
  • tobacco
  • tuberculosis
  • urinary tract disease

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Authors

  • Nojgaard C.

  • Matzen P.

  • Bendtsen F.

  • Andersen J.R.

  • Christensen E.

  • Becker U.

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