FANCD2 Hurdles the DNA Interstrand Crosslink

  • Moldovan G
  • D'Andrea A
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Left unrepaired, DNA interstrand crosslinks represent impassable hurdles for DNA replication, and their removal is a complicated stepwise process involving a variety of enzymes. In a recent paper in Science, Knipscheer et al. (2009) demonstrate that the Fanconi Anemia protein FANCD2 promotes multiple steps of the crosslink repair process. © 2009 Elsevier Inc. All rights reserved.

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  • George Lucian Moldovan

  • Alan D. D'Andrea

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