Activation of the Fanconi anemia (FA) DNA damage-response pathway results in the monoubiquitination of FANCD2, which is regulated by the nuclear FA core ubiquitin ligase complex. A FANCD2 protein sequence-based homology search facilitated the discovery of FANCI, a second monoubiquitinated component of the FA pathway. Biallelic mutations in the gene coding for this protein were found in cells from four FA patients, including an FA-I reference cell line. © 2007 Nature Publishing Group.
CITATION STYLE
Sims, A. E., Spiteri, E., Sims, R. J., Arita, A. G., Lach, F. P., Landers, T., … Huang, T. T. (2007). FANCI is a second monoubiquitinated member of the Fanconi anemia pathway. Nature Structural and Molecular Biology, 14(6), 564–567. https://doi.org/10.1038/nsmb1252
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