FANCI is a second monoubiquitinated member of the Fanconi anemia pathway

  • Sims A
  • Spiteri E
  • Sims R
 et al. 
  • 68

    Readers

    Mendeley users who have this article in their library.
  • 189

    Citations

    Citations of this article.

Abstract

Activation of the Fanconi anemia (FA) DNA damage-response pathway results in the monoubiquitination of FANCD2, which is regulated by the nuclear FA core ubiquitin ligase complex. A FANCD2 protein sequence-based homology search facilitated the discovery of FANCI, a second monoubiquitinated component of the FA pathway. Biallelic mutations in the gene coding for this protein were found in cells from four FA patients, including an FA-I reference cell line.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Ashley E. Sims

  • Elizabeth Spiteri

  • Robert J. Sims

  • Adriana G. Arita

  • Francis P. Lach

  • Thomas Landers

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free