Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum

  • Mosel D
  • Dumitru R
  • Hornby J
 et al. 
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Concentrations of (E,E)-farnesol needed to inhibit germ tube formation were determined for Candida albicans strains A72 and SC5314 by using six different conditions known to trigger germination. For defined media, 1 to 2 microM farnesol was sufficient. However, with serum at 2 to 20%, up to 250 microM farnesol was required. Farnesol blocked germ tube formation but did not block elongation of existing germ tubes.

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  • Daniel D. Mosel

  • Raluca Dumitru

  • Jacob M. Hornby

  • Audrey L. Atkin

  • Kenneth W. Nickerson

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