Fat and bone

  • I.R. R
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Abstract

Body weight is a principal determinant of bone density and fracture risk, and adipose tissue mass is a major contributor to this relationship. In contrast, some recent studies have argued that " fat mass after adjustment for body weight" actually has a deleterious effect on bone, but these analyses are confounded by the co-linearity between the variables studied, and therefore have produced misleading results. Mechanistically, fat and bone are linked by a multitude of pathways, which ultimately serve the function of providing a skeleton appropriate to the mass of adipose tissue it is carrying. Adiponectin, insulin/amylin/preptin, leptin and adipocytic estrogens are all likely to be involved in this connection. In the clinic, the key issues are that obesity is protective against osteoporosis, but underweight is a major preventable risk factor for fractures. 2010 Elsevier Inc.

Author-supplied keywords

  • *adipose tissue
  • *bone
  • adipocyte
  • adiponectin/ec [Endogenous Compound]
  • body mass
  • body weight
  • bone density
  • bone growth
  • bone mineral
  • computer assisted tomography
  • deoxypyridinoline/ec [Endogenous Compound]
  • dual energy X ray absorptiometry
  • estrogen/ec [Endogenous Compound]
  • feeding
  • fracture
  • hip
  • hip fracture
  • insulin sensitivity
  • insulin/ec [Endogenous Compound]
  • lean body weight
  • leptin/ec [Endogenous Compound]
  • menopause
  • morphometrics
  • osteoblast
  • osteoclastogenesis
  • osteoporosis
  • pancreas islet beta cell
  • postmenopause
  • premenopause
  • priority journal
  • resistin/ec [Endogenous Compound]
  • review
  • risk factor
  • rosiglitazone
  • sex hormone/ec [Endogenous Compound]
  • signal transduction
  • soft tissue
  • trabecular bone
  • vertebra fracture

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Authors

  • Reid I.R.

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