Fat metabolism links germline stem cells and longevity in C. elegans

299Citations
Citations of this article
334Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Fat metabolism, reproduction, and aging are intertwined regulatory axes; however, the mechanism by which they are coupled remains poorly understood. We found that germline stem cells (GSCs) actively modulate lipid hydrolysis in Caenorhabditis elegans, which in turn regulates longevity. GSC arrest promotes systemic lipolysis via induction of a specific fat lipase. Subsequently, fat mobilization is promoted and life span is prolonged. Constitutive expression of this lipase in fat storage tissue generates lean and long-lived animals. This lipase is a key factor in the lipid hydrolysis and increased longevity that are induced by decreased insulin signaling. These results suggest a link between C. elegans fat metabolism and longevity.

Cite

CITATION STYLE

APA

Wang, M. C., O’Rourke, E. J., & Ruvkun, G. (2008). Fat metabolism links germline stem cells and longevity in C. elegans. Science, 322(5903), 957–960. https://doi.org/10.1126/science.1162011

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free