Fatal cyclobenzaprine overdose with postmortem values.

  • Spiller H
  • Cutino L
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There are only two published cases of overdose with postmortem blood cyclobenzaprine concentrations, both with confounding factors. We report two additional cases of fatal cyclobenzaprine overdose with postmortem values. Case 1: a 56-year-old female was found in full cardiopulmonary arrest after a verbal suicide threat to a friend. Postmortem blood concentrations were cyclobenzaprine 0.96 mg/L and diazepam 0.3 mg/L. Case 2: a 37-year-old male was found in full arrest by a family member after an intentional ingestion of cyclobenzaprine. Postmortem blood concentrations were cyclobenzaprine 0.8 mg/L and ethanol 0.174 gm/dL. The concentrations of diazepam and ethanol reported in these two patients were not found in quantities usually associated with a fatal outcome, suggesting that the cyclobenzaprine was the primary cause of the fatality. Additionally, the blood was drawn from a femoral site, so that postmortem redistribution is not a likely factor. Blood concentration of > or = 0.8 mg/L cyclobenzaprine may be associated with a fatal outcome.

Author-supplied keywords

  • Adult
  • Amitriptyline
  • Amitriptyline: analogs & derivatives
  • Amitriptyline: blood
  • Amitriptyline: chemistry
  • Amitriptyline: poisoning
  • Analgesics, Non-Narcotic
  • Analgesics, Non-Narcotic: blood
  • Analgesics, Non-Narcotic: chemistry
  • Analgesics, Non-Narcotic: poisoning
  • Diazepam
  • Diazepam: blood
  • Drug Overdose
  • Ethanol
  • Ethanol: blood
  • Female
  • Humans
  • Male
  • Middle Aged
  • Molecular Structure
  • Muscle Relaxants, Central
  • Muscle Relaxants, Central: blood
  • Suicide

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  • PMID: 12877312
  • PUI: 36801483
  • SGR: 0038387647
  • SCOPUS: 2-s2.0-0038387647
  • ISSN: 0022-1198


  • Henry a Spiller

  • Letizia Cutino

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