Fatty Liver Index in Polycystic Ovary Syndrome

  • Lerchbaum E
  • Gruber H
  • Schwetz V
 et al. 
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Abstract

Introduction: Women with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances and might be affected by hepatic steatosis. The fatty liver index (FLI) was developed as a simple and accurate predictor of hepatic steatosis. We aimed to analyze the association of FLI with endocrine and metabolic parameters in a cohort of PCOS and control women.Methods: FLI was calculated using BMI, waist circumference (WC), triglycerides (TG) and gamma-glutamyl transferase (GGT) in 611 PCOS and 139 BMI-matched control women within the same age range. Elevated FLI was defined as >60. Metabolic, endocrine, and anthropometric measurements and oral glucose tolerance tests were performed.Results: PCOS women had significantly higher FLI levels than control women in age-adjusted analyses (11.4 [4.3-48.8] and 8.8 [3.9-35.0], respectively, p=0.001), whereas fibrosis indices were similar (AST-to-platelet-ratio-index) or lower (FIB-4), respectively. In binary logistic regression analysis adjusted for age, OR for elevated FLI was 2.52 (1.31-4.85), p=0.006, for PCOS women when compared to controls. PCOS women with high FLI levels had an adverse anthropometric, metabolic and endocrine risk profile. The prevalence of elevated FLI was 88.7% in PCOS women with metabolic syndrome (MS) and 11.3% in PCOS women without MS (p

Author-supplied keywords

  • Liver
  • PM 2011 37
  • Prevalence
  • Regression Analysis
  • Risk
  • Triglycerides
  • analysis

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  • PMID: 21937505

Authors

  • E Lerchbaum

  • H J Gruber

  • V Schwetz

  • A Giuliani

  • R Moeller

  • T R Pieber

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