FDG-PET for assessment of early treatment response after four cycles of chemotherapy in patients with advanced-stage Hodgkin's lymphoma has a high negative predictive value

  • Marková J
  • Kobe C
  • Skopalova M
 et al. 
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


BACKGROUND: As positron emission tomography (PET) seems to be a powerful prognostic marker in the treatment of Hodgkin's lymphoma (HL), we analysed the prognostic value of PET after four cycles of combination therapy with bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine and prednisone (BEACOPP) in patients with advanced-stage HL. PATIENTS AND METHODS: From January 2004 to March 2007, 50 patients with newly diagnosed HL in clinical stages IIB with large mediastinal mass or extranodal disease, III and IV were treated according to the HD15 protocol of the German Hodgkin Study Group. All patients received a PET scan after four cycles of BEACOPP (PET-4). RESULTS: Of the overall group, 14 of 50 patients had a positive PET-4 while 36 had a negative PET-4. At a median observation time of 25 months, 2 of the 14 patients with a positive PET-4 had progressed or relapsed, while there was no progression or relapse in PET-4-negative patients. CONCLUSION: Our results indicate a very good negative predictive value of PET-4 in advanced-stage HL patients treated with BEACOPP

Author-supplied keywords

  • Bleomycin
  • Cyclophosphamide
  • Disease
  • Doxorubicin
  • Etoposide
  • Hematology
  • Lymphoma
  • Medicine
  • Observation
  • Patients
  • Prednisone
  • Procarbazine
  • Time
  • Tomography
  • Universities
  • Vincristine
  • chemotherapy
  • methods
  • therapy

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in


  • J Marková

  • C Kobe

  • M Skopalova

  • K Klaskova

  • K Dedeckova

  • A Plutschow

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free